Molecular Pathways and TCM Pharmacology of Breast Cancer by M.M. Van Benschoten, OMS
Ms. A is a 65 yr old female tumor right breast, previous immunotherapy of unknown ingredients by unlicensed practitioner with progression of disease. Biopsy 2/14 ER+, inoperable due to large size. Femara from 3/14 through 7/14 was ineffective, on 8/14 Abraxane chemotherapy x 5, increasing tumor markers, PET scan reveals bone and lung metastasis. With onset of liver failure, MD recommends hospice with 1-2 months life expectancy. After a stent was placed in bile duct for metastatic blockage, patient starts a plant based diet, continues herbs with no chemotherapy, and tumor markers are reduced on the next series of lab tests. On 10/14 a biopsy sample was sent to Foundation One for genetic testing.
Genomic alterations
FGF, PI3K, MAPK, VEGFR1, Cyclin D1, C-myc, RUNX1, E-cadherin, mTOR, aurora
Tumor markers CA 27.29
6/11/14 392
9/24/14 1128
10/30/14 954
4/15/14
scutellaria barbata (Ban Zhi Lian (Herba Scutellariae Barbatae)), gleditsia thorn (Zao Jiao Ci (Spina Gleditsiae)), mastic (Ru Xiang (Gummi Olibanum)), ligustrum (Nu Zhen Zi (Fructus Ligustri Lucidi)), coix (Yi Yi Ren (Semen Coicis)), epimedium (Yin Yang Huo (Herba Epimedii)), rubus (Fu Pen Zi (Fructus Rubi)), tokoro (Fen Bi Xie (Rhizoma Dioscoreae Hypoglaucae)), hibiscus (Fu Rong (Radix Hibisci)), prunella (Xia Ku Cao (Spica Prunellae)), lycium fruit (Gou Qi Zi (Fructus Lycii)), pseudostellaria (Tai Zi Shen (Radix Pseudostellariae))
6/9/14
add andrographis (Chuan Xin Lian (Herba Andrographis)), oldenlandia (Bai Hua She She Cao (Herba Hedyotis))
6/23/14
add acanthopanax (Wu Jia Pi (Cortex Acanthopanacis)), lycopodium seriatim (Qian Ceng Ta (Herba Lycopodii Serrati))
7/14/14
grape seed (Pu Tao Zi (Herba Taraxaci)), luffa (Si Gua Luo (Retinervus Luffae Fructus)), corydalis (Yan Hu Suo (Rhizoma Corydalis)), trichosanthes fruit (Gua Lou (Fructus Trichosanthis)), cimicifuga (Sheng Ma (Rhizoma Cimicifugae)), echinops (Lou Lu (Radix Rhapontici)), paris (Qi Ye Lian (Radix Schefflerae)), physalis (Pao Zai Cao (Herba Physalis Angulatae))
10/7/14
Bupleurum (Chai Hu (Radix Bupleuri)), gynostemma (Jiao Gu Lan (Rhizoma seu Herba Gynostemmatis)), silybum (Shui Fei Ji (Fructus Silybi)), rhodiola (Hong Jing Tian (Radix et Rhizoma Rhodiolae Crenulatae)), solidago (Liu Zhi Huang (Herba Solidaginis)), anemarrhena (Zhi Mu (Rhizoma Anemarrhenae)), inula (Xuan Fu Hua (Flos Inulae)), ganoderma (Ling Zhi (Ganoderma)), loranthus (Sang Ji Sheng (Herba Taxilli)), curcuma longa (Jiang Huang (Rhizoma Curcumae Longae))
10/24/14
Cordyceps (Dong Chong Xia Cao (Cordyceps)), lobelia (Ban Bian Lian (Herba Lobeliae Chinensis)), scirpus (San Leng (Rhizoma Sparganii)), solanum nigrum (Long Kui (Herba Solani Nigri)), artemisia annua (Qing Hao (Herba Artemisiae Annuae)), physalis (Pao Zai Cao (Herba Physalis Angulatae)), carthamus (Hong Hua (Flos Carthami)), cyathula (Chuan Niu Xi (Radix Cyathulae)), poria (Fu Ling (Poria)), jujube (Da Zao (Fructus Jujubae))
11/7/14
Siegesbeckia (Xi Xian Cao (Herba Siegesbeckiae)), ganoderma (Ling Zhi (Ganoderma)), chrysanthemum indicum (Ju Hua (Flos Chrysanthemi)), picrorhiza (Hu Huang Lian (Rhizoma Picrorhizae)), arctium (Niu Bang Zi (Fructus Arctii)), sophora subprostrata (Shan Dou Gen (Radix et Rhizoma Sophorae Tonkinensis)), hibiscus (Fu Rong (Radix Hibisci)), oldenlandia (Bai Hua She She Cao (Herba Hedyotis))
12/4/14
ocimum (Luo Le Shu (Ocimum Linnaeus)), corydalis (Yan Hu Suo (Rhizoma Corydalis)), lindera (Wu Yao (Radix Linderae)), sargassum (Hai Zao (Sargassum)), carthamus (Hong Hua (Flos Carthami)), eupatorium chinensis (Tu Niu Xi (Tuniuxi Root))
Foundation One Gene Assay
genomic alterations, therapeutic implications, FDA approved therapies, potential clinical trials
Pharmacologic Targets
Anticancer-breast/Cyclin D1 inhibit
Ailanthus (Chun Pi (Cortex Ailanthi))
antrodia (Niu Zhang Zhi (Antrodia Camphorata Mushroom))
artemisia annua (Qing Hao (Herba Artemisiae Annuae))
camellia (Cha Hua)
curcuma longa (Jiang Huang (Rhizoma Curcumae Longae))
ganoderma (Ling Zhi (Ganoderma))
gynostemma (Jiao Gu Lan (Rhizoma seu Herba Gynostemmatis))
momordica charantia (Ku Gua (Bitter Melon))
pueraria (Ge Gen (Radix Puerariae Lobatae))
sesame (Hei Zhi Ma (Semen Sesami Nigrum))
silybum (Shui Fei Ji (Fructus Silybi))
tribulus (Ji Li (Fructus Tribuli))
Anticancer-breast/Fibroblast growth factor inhibit
camellia (Cha Hua)
citrus peel (Chen Pi (Pericarpium Citri Reticulatae))
cordyceps (Dong Chong Xia Cao (Cordyceps))
salvia (Dan Shen (Radix et Rhizoma Salviae Miltiorrhizae))
Anticancer-breast/Phosphatidylinositol 3 kinase inhibit
camellia (Cha Hua)
evodia (Wu Zhu Yu (Fructus Evodiae))
ganoderma (Ling Zhi (Ganoderma))
gingko leaf Yin Xing Ye (Folium Ginkgo)
grape seed (Pu Tao Zi (Herba Taraxaci))
hibiscus (Fu Rong (Radix Hibisci))
inula (Xuan Fu Hua (Flos Inulae))
E-cadherin upregulate
artemisia annua (Qing Hao (Herba Artemisiae Annuae))
cordyceps (Dong Chong Xia Cao (Cordyceps)),
garlic
grape seed (Pu Tao Zi (Herba Taraxaci))
hibiscus (Fu Rong (Radix Hibisci))
ocimum (Luo Le Shu (Ocimum Linnaeus))
salvia (Dan Shen (Radix et Rhizoma Salviae Miltiorrhizae))
scute (Huang Qin (Radix Scutellariae))
mTOR inhibit
agastache (Huo Xiang (Herba Agastaches))
anemarrhena (Zhi Mu (Rhizoma Anemarrhenae))
clove (Ding Xiang (Flos Caryophylli))
eriobotrya (Pi Pa Ye (Folium Eriobotryae))
ligustrum (Nu Zhen Zi (Fructus Ligustri Lucidi))
loranthus (Sang Ji Sheng (Herba Taxilli))
oldenlandia (Bai Hua She She Cao (Herba Hedyotis))
plantago (Che Qian Cao (Herba Plantaginis))
prunella (Xia Ku Cao (Spica Prunellae))
p38 MAPK blocking
chrysanthemum indicum
curcuma longa (Jiang Huang (Rhizoma Curcumae Longae))
ganoderma (Ling Zhi (Ganoderma))
lycopus (Ze Lan (Herba Lycopi))
mume(Wu Mei (Fructus Mume))
paeony red (Chi Shao (Radix Paeoniae Rubra))
pyrola (Lu Xian Cao (Herba Pyrolae))
sesame (Hei Zhi Ma (Semen Sesami Nigrum))
sophora flower (Huai Hua (Flos Sophorae))
VEGF decrease
andrographis (Chuan Xin Lian (Herba Andrographis))
anemarrhena (Zhi Mu (Rhizoma Anemarrhenae))
antrodia (Niu Zhang Zhi (Antrodia Camphorata Mushroom))
camellia (Cha Hua)
coriolus (Yun Zhi (Coriolus))
curcuma longa (Jiang Huang (Rhizoma Curcumae Longae))
ganoderma (Ling Zhi (Ganoderma))
ginger (Sheng Jiang (Rhizoma Zingiberis Recens))
gingko leaf Yin Xing Ye (Folium Ginkgo)
gleditsia thorn (Zao Jiao Ci (Spina Gleditsiae))
grifola frondosa (Hai Shu Hua (Maitake)
leonurus (Shi Diao Lan (Herba Lysionoti))
lindera (Wu Yao (Radix Linderae)),
paeony red (Chi Shao (Radix Paeoniae Rubra))
piper longum (Bi Bo (Fructus Piperis Longi))
sargassum (Hai Zao (Sargassum))
scirpus (San Leng (Rhizoma Sparganii))
scute (Huang Qin (Radix Scutellariae))
sesame (Hei Zhi Ma (Semen Sesami Nigrum))
tripterygium (Lei Gong Teng (Radix Tripterygii Wilfordii))